You May Not Feel It… Until It’s Kidney Failure
- Pharm. Onyehalu Jennifer

- Apr 7
- 3 min read
The Kidney
The kidneys are two bean-shaped organs located at the back of the abdomen, one on each side of the spine. They are vital for maintaining the body’s internal balance.
Major Functions of the Kidneys
The kidneys perform several important functions:
Filtering waste products from the blood and removing them through urine
Maintaining fluid balance in the body
Regulating electrolytes such as sodium, potassium, and calcium
Controlling blood pressure through hormone regulation
Producing hormones that support red blood cell production and bone health

What Is Kidney Failure?
Kidney Failure occurs when the kidneys lose their ability to perform these essential functions effectively.
As a result:
Waste products accumulate in the blood
Fluid balance is disrupted
Electrolyte levels become abnormal
This can lead to serious complications affecting multiple organs.
Prevalence of Kidney Failure
Kidney Failure is a growing global health concern, affecting millions of people worldwide.
Globally, over 850 million people are estimated to have some form of kidney disease, including Chronic Kidney Disease
About 10% of the world’s population is affected by chronic kidney disease
Millions of people progress to kidney failure, requiring dialysis or kidney transplantation to survive
Types of Kidney Failure
1. Acute Kidney Failure
Also known as Acute Kidney Injury, this occurs suddenly, often within hours or days.
Common causes include:
Severe dehydration
Infections
Blood loss
Certain medications
It is often reversible if treated early.
2. Chronic Kidney Failure
Also known as Chronic Kidney Disease, this develops gradually over time.
It is usually permanent and may progress to end-stage kidney disease.
Causes of Kidney Failure
1. Diabetes
Diabetes is the leading cause of chronic kidney failure due to long-term damage to blood vessels in the kidneys. More than 35% of people aged 20 years or older with diabetes have CKD.
2. High Blood Pressure
Hypertension damages the kidney’s filtering units over time. More than 20% of people aged 20 years or older with hypertension have CKD.
3. Infections
Severe infections can impair kidney function.
4. Medications and Toxins
Certain substances can damage the kidneys, especially when used improperly or for long periods.
Examples include:
Pain relievers (NSAIDs): Ibuprofen, diclofenac, naproxen
Herbal remedies with unknown or harmful components
Heavy metals: lead, mercury
Excessive use of over-the-counter drugs
5. Obstruction
Conditions like kidney stones or an enlarged prostate can block urine flow.

Signs and Symptoms
Kidney failure may not show symptoms early, but as it progresses, you may notice:
Swelling of the legs, ankles, or face
Fatigue and weakness
Reduced urine output
Nausea and vomiting
Difficulty concentrating
Shortness of breath
Why Is Kidney Failure Dangerous?
Kidney Failure is serious because the kidneys play vital roles in:
Removing waste products
Balancing fluids and electrolytes
Regulating blood pressure
When they fail, complications can include:
Fluid overload
Heart problems
Severe electrolyte imbalance
Death if untreated
Diagnosis
Doctors may use:
Blood tests (to check waste levels like creatinine)
Urine tests
Imaging scans
Kidney biopsy (in some cases)
Treatment Options
Treatment depends on the severity and cause.
1. Managing the Cause
Controlling blood sugar in diabetes
Managing blood pressure
Treating infections
2. Medications
Used to manage symptoms and complications.
3. Dialysis
A procedure that removes waste and excess fluid when the kidneys can no longer function properly.
4. Kidney Transplant
In severe cases, replacing the damaged kidney with a healthy one.

Prevention
You can reduce your risk by:
Maintaining healthy blood sugar levels
Controlling blood pressure
Staying hydrated
Avoiding misuse of medications
Going for regular health check-ups
When Should You See a Doctor?
Seek medical attention if you notice:
Persistent swelling
Changes in urination
Unexplained fatigue
Symptoms of chronic conditions like diabetes or hypertension
Final Thoughts
Kidney Failure is a serious condition, but early detection and proper management can make a significant difference.
Taking care of your overall health, especially managing conditions like diabetes and hypertension, is key to protecting your kidneys.
Your kidneys may be silent, but their health speaks loudly through your overall well-being.











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